不同透析膜对维持性血液透析患者微炎症状态的影响

Effects of different hemodialysis membrane on microinflammatory status in maintenance hemodialysis patients

目的:探讨不同透析膜对维持性血液透析患者微炎症状态的影响。方法:选取尿毒症透析患者36例,分为F60组(使用高通量聚砜膜透析器F60)和CA130组(使用低通量醋酸纤维素膜透析器CA130),另选取20例健康体检者作为正常对照组,监测治疗前后患者炎症指标水平的变化。结果:与正常对照组比较,治疗前尿毒症患者的血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平均显著升高,而白蛋白(ALB)水平显著降低。血液透析治疗8个月后,F60组患者CRP、IL-6水平明显下降,ALB水平明显升高。结论:维持性血液透析患者存在着微炎症状态,高通量合成膜治疗能够显著改善维持性血液透析患者的微炎症状态。

Objective To investigate the effects of different hemodialysis membrane on microinflammatory status in the patients with maintenance hemodialysis, Methods Thrity-six uremic patients were divided into F60 group and CA130 group and another 20 healthy people were taken as normal control group, The concentrations of serum C-reactive protein （CRP） and interleukin-6 （IL-6） were detected, Results Compared with the normal control group, the concentrations of CRP and IL-6 in both F60 group and CA130 group before statin treatment were much higher than those in normal control group, while the concentrations of plasma albumin in both F60 group and CA130 group were significantly lower than that in normal control group, The concentrations of CRP and IL-6 decreased markedly, and the concentrations of plasma albumin increased significantly in F60 group after being treated with hemodialysis therapy for 8 months. Conclusions Microinflammatory status exists in the maintenance hemodialysis patients, The microinflammation in patients with uremia can be inhibited effectively by high flux hemodialysis membrane therapy.