生存素及血管内皮生长因子在结肠腺瘤性息肉及腺癌中的表达

Expressions of survivin and vascular endothelial growth factor in colonic adenomatous polyp and colon adenocarcinoma

目的:探讨非家族性大肠腺瘤性息肉及腺癌中生存素(survivin)及血管内皮生长因子(VEGF)的表达,为预测腺瘤性息肉癌变提供理论基础。方法:收集我院2004年1月至2005年12月大肠腺瘤性息肉及腺癌标本,利用免疫组化技术分别检测40例腺瘤性息肉,40例大肠腺癌及相应的正常黏膜对照中survivin、VEGF的表达情况。结果:Survivin、VEGF的表达强度均依次为腺瘤黏膜对照组<腺癌黏膜对照组<腺瘤组<腺癌组,survivin及VEGF在正常黏膜与腺瘤性息肉及腺癌中的表达依次增强,且均有统计学意义(均P<0.01)。结论:VEGF在腺瘤的增生、癌变、肿瘤的形成、生长和血管形成中起重要作用。Survivin可能是大肠腺瘤发展及癌变过程中的重要促进因子,对于预测大肠腺瘤癌变可能性及化学干预有重要意义。

Objective To explore the expressions of survivin and vascular endothelial growth factor（VEGF） expression in non-familial colonic adenomatous polyp and adenocarcinoma to provide the theoretical supports for predicting the oncogenesis of adenomatous polyp. Methods Immunohistochemical staining was conducted to detect the expressions of survivin and VEGF protein in 40 adenomatous polyps, 40 adenocarcinomas, and the normal mucosal controls. Results The expression levels of survivin and VEGF from high to low ranged as follow： adenocarcinoma, adenomatous polyp, mucosal control for adenocarcinoma, and control for adenomatous polyp. Conclusions VEGF plays an important role in the proliferation of adenomatous polyp cells, carcinogenesis, formation and growth of adenocarcinoma, and angiogenesis, survivin may be a promoting factor in the development and oncogenesis of colonic adenomatous polyposis and has critical significance in predicting carcinogenesis of adenomatous polyposis and in intervention with chemotherapy.