nAch受体在嗅觉编码中作用的仿真研究

Computer Simulation of nAch Receptor Mechanisms in Olfactory Coding

蝗虫触角叶的电生理实验表明气味刺激期间,其兴奋性细胞(PNs)反应与嗅物质的性质有关,PNs的放电活动所呈现不同的时空编码模式来识别不同的气味。以H-H方程为基础,结合了最新离子通道的研究成果,建立了蝗虫触角叶仿真模型。并在此基础上,通过改变烟碱乙酰胆碱能的(nAch,兴奋性神经递质)突触电流的仿真参数,研究兴奋性联接对嗅觉时空编码的影响。根据MATLAB仿真结果分析表明:阻断nAch能的突触联接会影响PNs的响应模式,具体表现在与局部场电压(LFP)保持同步的PNs的个数将会下降。

Electrophysiological measurements in the locust antennal lobe have suggested that the odors can affect the response of excitatory projection neurons （PNs）, and the firing activities of PNs present different spatiotemporal patterns correspondingly to different odors. Based on H - H formulation, a model of locust antennal lobe presented in this paper has incorporated recent experimental findings of ion channels. The paper investigates the influence of excitatory connections on the spatiotemporal olfactory coding by changing parameters of nAchergic synaptic currents. The MATLAB emulation result has shown that response patterns of PNs could be affected by blocking nAchergic syn- apses leading to a decrease in the number of PNs synchronized with the local field potential.