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PPARγ:一个IBD治疗的新靶点 被引量：2

PPARγ: a new therapeutic target in inflammatory bowel diseases
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摘要 脂质过氧化物酶体增殖物激活受体(PPAR)属于核受体家族。PPARγ配体通过PPARγ依赖或PPARγ不依赖的途径,在调节肠道炎症中起重要作用,有可能成为炎症性肠病的新治疗靶点。其作用机制尚不完全明确,报道较少。 Peroxisome proliferators acteivated receptors（PPAR） are members of nuclear receptor family. Ligand of PPARγ can modulate inflammation of colon through PPARγ dependent or independent way, PPARγ can be a new therapeutic target in inflammatory bowel diseases. The mechanisms of the therapy are not completely clear.
作者 方优红 陈春晓
机构地区 浙江大学医学院附属第一医院消化科
出处 《国际消化病杂志》 CAS 2008年第4期270-272,共3页 International Journal of Digestive Diseases
关键词 PPARΓ 炎症性肠病 溃疡性结肠炎 克罗恩病 PPARγ Inflammatory bowel disease Crohn＇s disease Ulcerative colitis
分类号 R574 [医药卫生—消化系统]
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参考文献19

  • 1Zhu Y, Alvares K, Huang Q, et al. Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem, 1993, 268: 26817-26820.
  • 2Lefebvre AM, Chen I, Desreumaux P, et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med, 1998, 4: 1053-1057.
  • 3McGovern DP, Hysi P, Ahmad T, et al. Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease. Hum Mol Genet, 2005, 14: 1245-1250.
  • 4Willson TM, Brown PJ, Sternbach DD, et al. The PPARs:from orphan receptors to drug discovery. J Med Chem, 2000,43: 527-550.
  • 5Bassaganya-Riera J, Reynolds K, Martino-Catt S, et al. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology, 2004, 127: 777-791.
  • 6Yki-Jarvinen H. Tiazolidinediones. N Engl J Med, 2004, 351: 1106-1118.
  • 7Rousseaux C, Lefebvre B, Dubuquoy L, et al. Intestinal antiin flammatory effect of 5-aminosalicylic acid is dependent on perox isome proliferator-activated receptor-gamma. J Exp Med, 2005 201 :1205-1215.
  • 8Dubuquoy L, Jansson EA, Deeb S, et al. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology, 2003, 124: 1265-1276.
  • 9Eun CS, Han DS, Lee SH, et al. Attenuation of colonic inflamination by PPARgamma in intestinal epithelial cells: Effect on TLR pathways. Gastroenterology, 2005, 128: T1526.
  • 10Lee SK, Kim HJ, Chi SG, et al. Saccharomyces boulardii activates expression of peroxisome proliferator-activated receptor-gamma in HT-29 cells. Korean J Gastroenterol, 2005, 45: 328-334.

同被引文献46

  • 1霍丽娟,赵和平.益生菌对溃疡性结肠炎大鼠结肠黏膜中IL-1和TNFα表达的影响[J].山西医科大学学报,2004,35(4):341-343. 被引量：16
  • 2易力,倪学勤,潘康成,汪洋.双歧杆菌的研究进展[J].兽药与饲料添加剂,2005,10(1):20-22. 被引量：11
  • 3谢龙山,余保平,谢桂珍,余秀兰,张章,范联.尘螨过敏母亲对新生儿Th1/Th2平衡功能的影响[J].实用医学杂志,2005,21(13):1410-1411. 被引量：6
  • 4乔万海,王静,师猛.罗格列酮对脂多糖诱导的多器官功能障碍综合征大鼠保护作用的研究[J].中国急救医学,2007,27(6):550-552. 被引量：8
  • 5TSAN M F, GAO Bao-chong. Pathogen-associated molecular pattern contamination as putative endogenou~ ligands of Toll-like receptors [ J]. J Endotoxln Res,2007,13 ( 1 ) :6-14.
  • 6de VRESE M, SCHREZENMEIR J. Probiotics, prebiotics, and synbiotics[ J ]. Adv Biochem Eng Biotechnol,2008,111 ( 1 ) : 1-66.
  • 7FULLER R. Probiotics in man and animals [ J ]. J Appl Bacterial, 1989,66 (5) :365-378.
  • 8SORRENTINO R ,de SOUZA P M ,SRISKANDAN S ,et al. Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function [ J ]. Br J Pharmacol,2008,154 (4) :864-871.
  • 9GOHRE V, SPALLEK T, HAWEKER H,et al. Plant pattern-recognition receptor FLS2 is directed for degradation by the bacterial ubiquitin ligase AvrPtoB[ J]. Curr Biol,2008,18(23 ) : 1824-1832.
  • 10RAKOFF-NAHOUM S, PAGLINO J, ESLAMI-VARZANEH F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis [ J ]. C ell, 2004,118 ( 2 ) : 229 -241.

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国际消化病杂志
2008年 第4期

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