IL-18与胃十二指肠疾病相关性研究进展

Progression of interaction between IL-18 and stomach duodenum disease

自1995年日本学者发现细胞因子IL-18以来,研究发现IL-18与众多临床疾病相关联。如自身免疫性疾病、变态反应性疾病、精神疾病、心脏疾病和肝损伤等。已有关于慢性胃炎患者胃黏膜组织内存在IL-18mRNA表达的报道。此文就IL-18自身特点及其与胃十二指肠疾病相关性研究进展进行综述。

Since 1995 the Japanese scholars discovered cytokine of IL-18, the results of the research have discovered that IL- 18 are connected with multitudinous clinical diseases, such as autoimmune disease, allergic disorder, mental disorder, myocardial disease and hepatic injury. Early there are reports about the chronic gastritis patient has IL-18 mRNA expression in human gastric biopsy specimens. This article reviewed the progression of the IL-18 own characteristic and its interaction with the stomach duodenum disease.