高压氧对脑损伤患者C补体系统影响的临床研究

Clinical Study of the Affection to Alexin System of Hyperbaric Oxygen Therapy of Brain Injury

目的研究早期应用高压氧治疗脑挫裂伤患者的补体C3、C4水平对防止肺部感染及肺氧中毒的作用。方法114例"脑挫裂伤"患者,随机分为高压氧治疗组和对照组,以格拉斯哥昏迷评分判断疗效,测定两组病人治疗前后血浆补体C3、C4水平变化并进行统计学分析。结果高压氧组治疗后血浆补体C3、C4水平较对照组明显增高;治疗后GCS昏迷评分高压氧治疗组较对照组得分增高明显。结论本研究评价了高压氧治疗脑挫裂伤患者后免疫功能的变化与病情、病程和预后的关系。

Objective To study the affection of C3, C4 level of brain injury patients treated by hyperbaric oxygen therapy to lung infection and lung oxygen toxicosis. Methods 114 cases with laceration and contusion of brain were divided randomly into two groups. One group treated with hyperbaric oxygen therapy, the other group as comparison and determined the clinical outcome with the Glasgow outcome scale. The C3, C4 level of the cases in two group before and after treated was measured and statistically analysed. Results The C3, C4 level of hyperbaric oxygen therapy group was significantly higher than that in comparison group. The Glasgow outcome scale after treated in hyperbaric oxygen therapy group was significantly higher than that in comparison group. Conclusion The study estimates the relationship between changes of the immune state of the brain injury patients treated by hyperbaric oxygen therapy and the state, course and the prognosis of diseases.