气管支气管淀粉样变1例报道及临床分析

One Case Report of Tracheobronchial Amyloidosis and Clinical Analysis

目的从病因、临床症状和体征、诊断和治疗等方面结合目前国内外的最新进展对呼吸系统淀粉样变进行探讨。方法我们诊治了1例临床少见病例。为58岁的老年妇女在6年前被诊断患有乳腺癌,后来继发出现了气管支气管淀粉样变,我们对其进行了马法兰和强的松联合化疗。结果这种联合治疗方案诱导了慢反应,并使疾病得到了部分的缓解。结论淀粉样变是一种罕见疾病,为一种特殊的蛋白质进展性地沉积在间质纤维,影响器官功能,甚至导致死亡。只要有可能,临床上就应当对患者进行试验性的治疗,如单纯化疗、高剂量的化疗联合外周血干细胞移植或低剂量的体外放疗。

Objective To discuss the respiratory tract amyloidosis through integrating the latest development at home and abroad horn the etiology,Presenting Symptoms and Signs,diagnosis and treatment areas. Methods We remedy a rare case of a 58-year-old female patient who was diagnosed with breast cancer 6 years ago and subsequently presented with tracheobronchial amyloidosis. Then the female patient was treated with a melphalan and prednisone regimen. Results This combination induced slow responses and led to partial remission of the disease. Conclusion Amyloidosis is a group of rare diseases in which a specific protein is deposited as aggregated interstitial fibrils that can compromise organ function and lead to death. Whenever possible,patients should be treated on clinical trials such as Chemotherapy alone, high-dose chemotherapy with peripheral blood stem cell transplant or low dose external beam radiation therapy.