生长激素缺乏症儿童血清瘦素、骨钙素水平变化及其相关性分析

Changes of Serum Leptin and Osteocalcin in Children with Growth Hormone Deficiency and Correlation between Leptin and Osteocalcin

目的观察生长激素缺乏症(GHD)儿童血清瘦素(LEP)、骨钙素(OC)水平的变化及两者相关性分析。方法分别测定32例GHD儿童重组人生长激素(rhGH)替代治疗前、治疗后3个月和35例性别、年龄匹配的正常健康儿童的血清LEP、OC,比较各组差异,并对LEP和OC进行相关性分析。结果GHD治疗前组血清LEP水平显著高于正常对照组(P<0.05),rhGH治疗3个月后LEP较基线值显著性降低。而GHD治疗前组血清OC水平显著低于正常对照组(P<0.05),rhGH治疗3个月后OC较基线值显著性增高,血清LEP、OC无显著相关性(r=0.281,P>0.05)。结论GHD儿童LEP水平的改变依赖于GH引起的体脂量的变化;GHD儿童骨代谢的调控很可能与LEP无关。

Objective To study changes of serum leptin and osteocalcin in children with growth hormone deficiency（GHD） and correlation beteen leptin and osteocalcin. Methods To measure serum leptin and osteocalcin respectively in 32 GHD children （before and after 3 months of recombinant human growth hormone therapy）and 35 sex- and agematched healthy controls. To analyse correlation beteen leptin and osteocalcin. Results Compared with the control,the serum levels of leptin in pre-treatment GHD group were significantly increased （P〈0.05）. Compared with the pre-treatment GHD group ,the serum levels of leptin in 3-inonth-treatment GHD group were significantly decreased （P〈0.05）. While,Compared with the control,the serum levels of osteocalcin in pre-treatment GHD group were significantly decreased （P〈0.05）. Compared with the pre-treatment GHD group, the serum levels of osteocalcin in 3-month-treatment GHD group were significantly increased（P〈0.05）. There was no significant con＇elation between leptin and osteocaicin（r = 0.281,P〉0.05）. Conclusion Changes of serum leptin in GHD children was depended on the change of body fat mass which was brought by GH. The adjustment and control of bone metabolism in GHD children might have no relationship with leptin.