1[1]Bates KR,Dodart JC,DeMattes DM,et al.Apolipop rotein E,amyloid and AlzheimerDisease[J].Mol Interv,2002,2(6):363-375.
2[2]American Psychiatric Association DSM-Ⅳ:diagnostic and statistical manual of mental disorders[M].4th ed.Washington:American Psy chiatric Association,1994:92-94.
3[3]Ignatius MJ,Gebicke-Harter PJ,Skene J HP,et al.Expression of apolipoprotein E during nerve degeneration and regeneration[J].Proc Natl Acad Sci USA,1986,83(4):1125-1129.
7[7]Manelli AM,Stine WB,Van Eldik LJ,et al.ApoE and Abetal 242 infractions:effects of isoform and conformation on structure and function[J].J Mol Neurosei,2004,23(3):235-246.
9[9]Tesseur I,Van Dorpe J,Spittaels K,et al.Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice[J].Am J Pathol,2000,156(3):951-964.
1Janus C, Peamon J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature, 2000, 408:979-982
2Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000, 408:982-985
3DeMattos RB, Bales KR, Cummins DJ, et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA,2001, 98:8850-8855
5Munch G, Robinson SR. Alzheimer's vaccine: a cure as dangerous as the disease? J Neural Transm, 2002, 109:537-539
6Hock C, Konietzko U, Streffer JR, et al. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron, 2003, 38:547-554
7McLaurin J, Cecal R, Kierstead ME, et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med, 2002, 8:1263-1269
8Lemere CA, Spooner ET, Leverone JF, et al. Amyloidbeta immunization in Alzheimer' s disease transgenic mouse models and wildtype mice. Neurochem Res, 2003,28:1017-1027
9Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid beta-protein similar tothat in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med, 1996, 2:864-8
10Golde TE, Eckman CB, Younkin SG, et al. Biochemical detection of Abeta isoforms: implications for pathogenesis,diagnosis, and treatment of Alzheimer's disease. Biochim Biophys Acta, 2000, 1502:172-187
