男性心绞痛患者白细胞性激素受体的变化

THE CHANGES OF SEX H0RMONES IN SERUM AND THEIR RECEPTORS OF LEUKOCYTES IN MALE PATIENTS WITH ANGINA PECTORIS

用放免法和放射配体结合法分别测定男性心绞痛病人血清性激素和白细胞性激素受体水平。结果表明与正常对照组相比，心绞痛组血清睾酮（T）和白细胞雄激江素最大的特异结合容量显著降低（P＜0．01）;血清雌二醇／每酮（E2／T）比率和白细胞雌江亲王大特异结合容量明显升高（P＜0．05～0．01），血清单二醇水平和雌激素及推激素受体的亲和力则无明显变化（P＞0．05）。揭示由血清睾降低引起的性激素失衡及性激素受体失衡是男性心绞痛的重要致病因子之一。

Different levels of serum testosterone (T) and estrodiol (E2) and the maximum of androgen re-ceptor (AR) and estrogen receptor (ER) in the peripheral intact leukocytes of 30 male patients with angina pec-toris were measured through radioimmunoassay and radio-ligand-binding assay respectively. The results indicatethat, in contrast with the normal control group, the patients with angina pector is showed a significantly de-creased level of serum testosterone and maximum of AR in the peripheral intact leukocytes (P<0.01), whilethe ratio of E2 t0 T (E2/T) and the maximum of ER in the peripheral intact leukocytes were greatly increased(P<0- 05-0. 01). There were no isgnificant difference in affinity of AR and ER of peripheral intact leukocytes.between the two groups. lt is suggested that the imbalance of sex hormone level may participate in the atheroge-nesis in male patients with angina pectoris.