辛伐他汀对稳定性冠心病患者的血清高敏C-反应蛋白水平的影响

Effect of Simvastatin on High Sensitivity C-reactive Protein in Serum of Patients with Stable Coronary Artery Disease

目的探讨辛伐他汀20mg/d对稳定性冠心病患者降脂达标率及血清高敏C-反应蛋白(hs-CRP)水平的影响。方法34例稳定性冠心病患者(其中男26例,女8例),年龄41～79岁,平均(64.4±11.3)岁,服用辛伐他汀20mg/d,疗程12周。治疗前、治疗4周及12周时分别检测血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、肌酐(Cr)、尿素氮(BUN)、尿酸(UA)、血糖(GLU)、肌酸激酶(CPK)及血清高敏C-反应蛋白(hs-CRP)。结果辛伐他汀20mg/d治疗12周降低TC、LDL-C、TG的幅度分别为34.8%、46.1%、24.7%;升高HDL-C2.0%,使76.5%冠心病患者LDL-C降至目标值,并可显著降低hs-CRP水平(P=0.018)。结论辛伐他汀20mg/d治疗冠心病患者有较高的降脂达标率,并可能有利于抑制炎症反应。

Objective To explore the effect of simvastatin on high sensitivity C-reactive protein in serum of patients with stable coronary artery disease. Methods 34 patients with stable coronary artery disease at the age of 41 -79 years old（26 males and 8 females, mean age at 64.4 ± 11.3 years old） were given 20 mg/d simvastatin at night. The therapeutic course was 12 weeks. Fasting serum total cholesterol （ TC ） , triglyceride （ TG ） , high density lipoprotein cholesterol （ HDL-C ） , low density lipoprotein cholesterol （ LDL-C ） , high sensitivity C-reactive protein（hs-CRP） and other biochemistry data were examined before and after 4 and 12 weeks＇ treatment. Results After 12 weeks＇ treatment, TC, LDL-C, TG significantly decreased by 34.8% , 46.1% and 24.7% , but HDL-C increased by 2.0% slightly. 76.5% patients could reach Chinese standard level of LDL-C, and the Hs-CRP level decreased significantly （ P = 0. 018 ）. Conclusion The use of 20 mg/d simvastatin is efficacious at lowering LDL-C levels and allowing patients to achieve their goal to low cholesterol level, and may be beneficial to inhibiting inflammatory response in patients with stable coronary artery disease.