摘要
神经炎症过程可能是阿尔采末病(AD)的重要发病原因之一。AD的流行病学研究显示,长期服用非甾体类抗炎药(NSAIDs)可减低AD的发病率;实验研究还发现,NSAIDs的作用除了调节COX机制外,还可能涉及一些非COX机制。
Neuroinflammation may be one of the causes in the pathogenesis of Alzheimer' s disease (AD), Epidemiological studies suggest that long-term use of nonsteroidal anti-inflammatory drugs (NSAII)s) can reduce the risk of AD. Laboratory evidence indicates that the protection of NSAIDs is mediated by inhibition of cyclooxygenase (COX) activity and the non-COX mechanisms. This review summarizes the possible underlying mechanisms in the action.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第8期988-992,共5页
Chinese Pharmacological Bulletin
关键词
阿尔采末病
非甾体类抗炎药
环氧合酶
Β淀粉样蛋白
过氧化物酶体增殖子活化受体γ
Alzheimer' s disease
nonsteroidal anti-inflammatory drugs
cyclooxygenase
β-amyloid peptide
peroxisome proliferator-activated receptor-γ