IFN-γ、IL-4、IL-10在川崎病患者血清中的表达和意义

Expression and significance of IFN-γ,L-4、IL-10 in serum of patients with Kawasaki disease

目的探讨IFN-γ、IL-4、IL-10在川崎病(KD)发病机制中的作用。方法采用病例-对照分析,使用双抗体夹心酶联免疫吸附试验(ELISA)方法,检测45例急性期KD患儿静脉注射丙种球蛋白(IVIG)前后血浆中的IFN-γ、IL-4、IL-10蛋白浓度与25例正常同年龄对照组的差异。结果急性期KD患儿血浆IFN-γ、IL-4、IL-10水平觉对照组明显上升,差异有统计学意义(P<0.01);给予IVIG治疗后,上述指标水平明显下降,差异有统计学意义(P<0.05)。结论IFN-γ、IL-4、IL-10可能通过调节T细胞活化的细胞因子机制参与KD发病的自身免疫耐受过程。

Objective To investigate the effects of IFN-γ,IL-4, IL-10 in pathogenesis of Kawasaki disease. Methods Detect the concentration of IFN-γ, IL-4, IL-10 in 45 patients with Kawasaki disease in a- cute stage before and after IG intravenous injection. At meantime, detect same indexes in 25 health children. Then compared the indexes between patients and health children. Results The concentration of IFN-γ, IL-4, IL-10 of 45 patients with Kawasaki disease in acute stage were increased significantly in comparison of health children. The concentration was decreased after IG intravenous injection. Conclusion IFN-γ,IL-4,IL-10 participate immune tolerance process of Kawasaki disease morbidity with adjusting activation of T cell.