氦-氧机械通气对大鼠急性肺损伤时肺组织形态的影响

Helium-Oxygen Mechanical Ventilation on Histomorphology in Acute Lung Injury Rat Models

目的探讨氦-氧机械通气对大鼠急性肺损伤(ALI)组织形态的影响。方法应用大鼠脓毒症性急性肺损伤模型,分别用空气-氧混合气和氦-氧混合气(Heliox)进行机械通气,进行肺系数测定以及肺组织炎症细胞计数,观察肺组织形态的差别。结果氦-氧机械通气对大鼠急性肺损伤模型的肺组织形态学变化未能产生影响。结论氦-氧机械通气不能改善大鼠急性肺损伤的组织形态,对大鼠急性肺损伤没有保护作用。

Objective To investigate the effect of helium-oxygen mechanical ventilation on histomorphology in acute lung injury（ALI） rat models. Methods To investigate the change of histomorphology in ALI rat models caused by sepsis by comparing air-oxygen mixture mechanical ventilation and helium-oxygen mixture mechanical ventilation. The lung coefficient was examined and took count of inflammatory cell in the lung tissue also. Results Helium-oxygen mechanical ventilation had no influence on the change of lung histomorphology. Conclusion Helium-oxygen mixture mechanical ventilation could not improve lung histomorphology,and had no protective effect on ALI rat models.