缺血性脑卒中患者血清C反应蛋白与选择素的变化及临床意义

Clinical Significance of Serum C-Reactive Protein and Selectin Levels in Patients with Cerebral Arterial Thrombosis

目的探讨 C 反应蛋白(CRP)、E-选择素和 P-选择素与缺血性脑卒中的关系及临床意义。方法分别应用免疫透射比浊法和 ELISA 方法测定50例缺血性脑卒中患者及30例正常人的 CRP、E-选择素和 P-选择素血清水平。结果缺血性脑卒中患者急性期血清 CRP、E-选择素和 P-选择素水平与恢复期、对照组的相比较显著升高(P<0.01);大面积梗死组(A 组)、中等面积梗死组(B 组)比小面积梗死组(C 组)3种检测指标明显升高,差异均具有统计学意义(P<0.01)。缺血性脑卒中患者急性期 CRP、E-选择素和 P-选择素水平之间均有正相关关系。结论血清 CRP、E-选择素和 P-选择素水平是缺血性脑卒中的有价值的标志物,可作为脑卒中发病进程和病情轻重的判断指标。

Objective To investigate the clinical significance of serum C-reactive protein, E-selectin and P-selectin levels in patients with cerebral arterial thrombosis. Methods 50 patients and 30 normal controls were enrolled. C-reavtive protein was measured by immuno-turbidimetry. Selection E and P levels were measured by enzyme linked immunosorbent assay （ELISA）. Results Serum C-reactive protein,E-selectin and P-selectin levels in acute phase patients were significantly higher than those in control and in recovery phase patients （ P 〈 0. 01 ） ; and their levels in macro-（ group A ） and middle-infarction group （ group B） were significantly higher than that in small - infarction group（ group C）. The levels of C- reactice protein, E-selectin and P-selectin were positively correlated with each other. Conclusion The C-reactive protein, E-selectin and P-selectin levels are valuable markers in patients with cerebral arterial thrombosis and can be used as criterion for the prognosis and monitoring these patients.