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嗜酸性粒细胞增多综合征2例并文献复习 被引量：2

Two Cases of Hypereosinophilic Syndrome in Children and Its Literature Review
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摘要 目的了解儿童特发性嗜酸性粒细胞(EOS)增多综合征(HES)的诊断及治疗特点。方法通过复习相关文献并结合本院2005年收治的2例HES患儿临床资料及实验室检查,了解本病的临床表现、诊断、鉴别诊断、治疗及儿童和成人患者的异同。结果2例患儿虽均表现为HES,但1例转归为恶性过程,最终考虑为EOS白血病;而另1例经治疗病情稳定。结论儿童HES表现有其自身特点,但仍以EOS增多引起脏器损伤为主要表现,而FIP1L1-PDGFRA融合基因检测及T淋巴细胞功能异常,对本病的诊断及治疗具有重要意义。
作者 朱光华 马晓莉 吴润晖 周翾 苏雁 吴敏媛
机构地区 首都医科大学附属北京儿童医院血液病中心
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第15期1186-1188,共3页 Journal of Applied Clinical Pediatrics
关键词 嗜酸性粒细胞增多综合征 FIP1L1-PDGFRA融合基因 儿童
分类号 R725.5 [医药卫生—儿科]
  • 相关文献

参考文献10

  • 1Chusid MJ, Dale DC, West BC,et al. The hypereosinophilic syndrome: Analysis of fourteen cases with review of the literature [ J ]. Medicine (Baltimore), 1975,54 ( 1 ) : 1 - 27.
  • 2Tefferi A. Blood eosinophilia.. A new paradigm in disease classification, diagnosis, and treatment [ J ]. Mayo Clin Proc,2005,80 ( 1 ) :75 - 83.
  • 3Katz HT, Haque S J, Hsieh F. Pediatric hypereosinophilic syndrome differs from adult HES [ J ]. J Pediatr,2005,146 ( 1 ): 134 - 136.
  • 4周文静,金洁.特发性嗜酸粒细胞增多综合征研究进展[J].国外医学（内科学分册）,2005,32(10):452-455. 被引量：5
  • 5Klion AD. Recent advances in the diagnosis and treatment of hypereosinophilic syndromes [ J ]. Hematology Am Soc Hematol Educ Program, 2005:209 - 214.
  • 6Bain B, Pierre R, Imbert M,et al. Chronic eosinophilic leukaemia and the hypereosinophilic syndrome [ M ]//Jaffe ES, Harris NL, Stein H, et al. World Health Organization of tumours:Tumours of haematopoiefic and lymphoid tissues. Lyon (France) :IARC Press ,2001:29 -31.
  • 7Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes [ J ]. Orphanet J Rare Dis ,2007,2:37.
  • 8张广森,李斌,裴敏飞,戴崇文,郑文莉,申建凯.高嗜酸性粒细胞综合征FIP1L1-PDGFRA融合基因和转录活化因子5蛋白检测[J].中华医学杂志,2004,84(18):1541-1544. 被引量：5
  • 9Gotlib J, Cools J, Malone JM,3rd ,et al. The FIP1L1 - PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia:Implications for diagnosis, classification, and management [ J ]. Blood,2004,103 ( 8 ) :2879 - 2891.
  • 10傅明伟,王建祥.伊马替尼治疗嗜酸粒细胞增多综合征[J].国外医学（输血及血液学分册）,2005,28(2):157-159. 被引量：1

二级参考文献47

  • 1Chusid MJ,David DC,West BC,et al. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine,1975,54(1):1-27.
  • 2Schaller JL,Burkland GA. Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate.Med Gen Med,2001,3(9):9.
  • 3Klion AD,Noel P,AkinC,et al. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis,poor prognosis and imatinib-responsiveness. Blood,2003,101(12):4660-4666.
  • 4Cortes J,Ault P,Koller C,et al. Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome.Blood,2003,101(12):4714-4716.
  • 5Buchdunger E,Zimmermann J,Mett H,et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine dervative. Cancer Res,1996,56(1):100-104.
  • 6Apperley JF,Gardembas M,Melo JV,et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor recertor beta.N Engl J Med,2002,347(7):481-487.
  • 7Ault P,Cortes J,Koller C,et al. Response of Idiopathic Hypereosinophilic Syndrome to Treatment with Imatinib Mesylate. Leuk Res,2002,26(9): 881-884.
  • 8Frickhofen N,Marker-Hermann E,Reiter A,et al. Complete molecular remission of chronic eosinophilic leukemia complicated by CNS disease after targeted therapy with imatinib. Ann Hematol,2004,83(7):477-480.
  • 9Pardanani A,Teeder T,Porrata LF,et al. Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders. Blood,2003,101(9):3391-3397.
  • 10Cools J,Deangelo DJ,Gotllib J,et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med,2003,348(13):1201-1214.

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实用儿科临床杂志
2008年 第15期

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