血清胆汁酸浓度测定在新生儿黄疸中的意义之探讨

Determination of Serum Bile Acid Concentrations in the Neonatal Jaundice of the Significance

目的:探讨新生儿黄疸与胆汁酸的关系。方法:将新生儿黄疸分为生理性黄疸组18例,病理性黄疸组80例。其中病理性黄疸组又分为缺血性组18例,感染性组25例,母乳性黄疸组18例,溶血性黄疸组7例,肝炎综合症组12例,测定各组血清胆汁酸浓度及相应部分统一标本的总胆红素。生理性黄疸胆酸浓度正常值12.28±5.41μmol/ L。结果:在不同病因引起的病理性黄疸中,各组总胆汁酸均高于生理性黄疸组,有显著差异。结论:胆汁酸增高在肝炎综合症组有辅助诊断意义。但在其它病理性黄疸中缺乏鉴剐诊断参考价值,母孕期胆汁酸增高对新生儿病理性黄疸是否有影响,需进一步研究。

Objective： To approach the relationship of neonatal jaundice and bile acid.Methods： Will be divided into physiological jaundice of the newborn jaundice group 18 cases, pathologic jaundice group of 80 cases. Which pathologic jaundice group divided into 18 cases of ischemic group, the Group of 25 cases of infection, breast milk jaundice group 18 cases, hemolytic jaundice group seven cases, 12 cases of hepatitis syndrome group, the determination of the serum bile acid concentration and the corresponding part of the total bilirubin were unified. Physiological jaundice acid concentration normal 12.28± 5.41μmol/L, respectively. Results： In the etiology arising from the different pathologic jaundice, the total bile acid group were higher than physiological jaundice group, a significant difference. Conclusions： Increased bile acid in the hepatitis group supporting SARS diagnostic significance. But in other pathologic differential diagnosis of jaundice in the absence of reference value, the mother during pregnancy increased bile acid pathologic jaundice of the newborn whether it will affect, for further study.