磁性纳米复合颗粒(Fe_3O_4/PVA)/SiO_2的制备与修饰

Synthesis and Modification of Superparamagnetic Nanocompositions(Fe_3O_4/PVA)/SiO_2

用三步合成法（共沉淀法、微乳液聚合、Stober过程）制备了（Fe3O4／PVA）／SiO2磁性纳米颗粒，并在颗粒表面进行了醛基化修饰。用TEM对不同工艺获得的颗粒形貌和结构进行了表征。结果表明，中间产物Fe3O4／PVAc颗粒的平均尺寸为100nm；终产物（Fe3O4／PVA）／SiO2的尺寸在100～500nm范围内是可调的。醛基化的（Fe3O4／PVA）／SiO2对BSA蛋白具有捕获能力，并且颗粒结合蛋白后具有一定的持久性和耐温性。

Nanocompositions （Fe3O4/PVA）/SiO2 have been prepared by three-step method （co-precipitation, miniemulsion polymerization, Stober process） and structurally characterized by TEM. According to the image of Fe3O4/PVA/SiO2 by TEM, the morphology is obviously core-shell structure： the average diameter of Fe3O4/PVAc is 100 nm; the diameter of （Fe3O4/PVA）/SiO2 is controllable within a certain range （100 - 500 nm）. And（Fe3O4/PVA）/SiO2-glutaraldehyde can capture BSA within a certain time at a certain temperature.