从青阳参提取的带7个糖残基的新C_(21)甾体苷(英文)

C21 steroidal glycosides with seven sugar residues extracted from Cynanchum otophyllum Schneid

目的:了解青阳参片中化合物的结构。方法:对青阳参(萝藦科)根茎的乙酸乙酯提取物(即青阳参片),用柱层析的方法分离,得到的纯化合物再用光谱方法测定结构。结果:分离出2个新的C21甾体苷,每个都有7个单糖残基。结构被分别确定为:告达亭3-O-α-L-磁麻吡喃糖基-(1→4)-α-D-夹竹桃吡喃糖基-(1→4)-α-L-磁麻吡喃糖基-(1→4)-β-D-葡萄吡喃糖基-(1→4)-α-D-夹竹桃吡喃糖基-(1→4)-β-D-夹竹桃吡喃糖基-(1→4)-β-D-2-脱氧毛地黄吡喃糖苷(1);和告达亭3-O-β-D-磁麻吡喃糖基-(1→4)-α-D-夹竹桃吡喃糖基-(1→4)-α-L-磁麻吡喃糖基-(1→4)-β-D-葡萄吡喃糖基-(1→4)-β-D-夹竹桃吡喃糖基-(1→4)-β-D-磁麻吡喃糖基-(1→4)-β-D-2-脱氧毛地黄吡喃糖苷(2)。结论:青阳参片中的C21甾体苷1和2,由一个C21甾体苷元部分和一个3-OH取代的糖链组成,7个单糖残基组成此链,糖残基为2-去氧己糖和葡萄糖,糖间的所有连接为1→4连接。

Objective：To investigate the structures of compounds in Qingyangshen tablets. Methods：The acetic ether extracts from the rhizome of Cynanchum otophyllum Schneid （Asclepiadaceae） was isolated by column chromatography, and the structures of the purified compounds were determined By spectral method. Results： Two new Celsteroidal glycosides were isolated whose structures were determined as caudatin 3- O- α - L - cymaropyranosyl - （1→4） - α - D - oleandropyranosyl - （1→4） - α - L - cymaropyranosyl - （1→4） - β - D - glucopyranosyl - （1→4） - α - D- oleandropyranosyl - （1→4） - β - D- oleandropyranosyl - （1→4） - - β -D - diginopyranoside （1）, and caudatin 3 - O- β - D- cymaropyranosyl - （1→4） - α - D- oleandropyranosyl - （1→4） - α - L- cymaropyranosyl - （1→4 ） - β - D - glucopyranosyl - （1 →4） - β - D - oleandropyranosyl （1→4 ） - β - D - cymaropyranosyl - （1→4） - β - D diginopyranoside （2）, respectively. Conclttsion： C21 steroidal glycosides 1 and 2 in Qingyangshen tablets are composed of a C21 steroidal aglycone moiety of the 3 - OH substitution and a sugar chain. This chain consists of seven sugar residues which are 2 - deoxy - hexose and glucose. All linkages between them are 1→4.