摘要
目的:研究依痰饮、肾虚不同论点立方对阿尔茨海默病(Alzheimer's disease,AD)小鼠脑组织脂质过氧化的不同影响。方法:采取D-半乳糖腹腔注射造成AD模型,分别给予吡拉西坦、茵陈五苓散和地黄饮子治疗,检测脑组织中丙二醛(MDA)含量和谷胱甘肽过氧化物酶(GSH-Px)活性。结果:茵陈五苓散和地黄饮子均能明显降低MDA,升高GSH-Px活性,地黄饮子作用更强。结论:二方均能改善脑组织脂质过氧化损伤。
Objective : To investigate the different inflution of brain tissue lipid peroxidation in Alzheimer' s disease ( AD ) mouse to dispense prescriptions according to phlegmatic theory or renal deficiency theory. Methods:Made model with injecting D-galactose in abdominal cavity.Teat with piracetam, Yinchen WulingSan or Dihuang Yinzi respectively.Test malondialdehyde(MDA) and glutathione peroxidase(GSH-Px) in brain tissue.Results: Yinchen WulingSan and Dihuang Yinzi obviously degraded MDA and advanced GSH-Px.The latter had more obviouse action.Conclusion:The two prescriptions could improve brain tissue lipid peroxidation dimnification.
出处
《辽宁中医药大学学报》
CAS
2008年第9期151-152,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
阿尔茨海默病
肾虚
痰饮
茵陈五苓散
地黄饮子
Alzheimer' s disease
renal deficiency theory
Phlegmatic theory
Yinchen WulingSan
Di huang Yinzi