依痰饮论 肾虚论立方对AD小鼠脑组织脂质过氧化的不同影响

Different inflution of brain tissue lipid peroxidation in Alzheimer’s disease mouse to dispense prescriptions:according to phlegmatic theory or renal deficiency theory

目的:研究依痰饮、肾虚不同论点立方对阿尔茨海默病(Alzheimer's disease,AD)小鼠脑组织脂质过氧化的不同影响。方法:采取D-半乳糖腹腔注射造成AD模型,分别给予吡拉西坦、茵陈五苓散和地黄饮子治疗,检测脑组织中丙二醛(MDA)含量和谷胱甘肽过氧化物酶(GSH-Px)活性。结果:茵陈五苓散和地黄饮子均能明显降低MDA,升高GSH-Px活性,地黄饮子作用更强。结论:二方均能改善脑组织脂质过氧化损伤。

Objective ： To investigate the different inflution of brain tissue lipid peroxidation in Alzheimer＇ s disease （ AD ） mouse to dispense prescriptions according to phlegmatic theory or renal deficiency theory. Methods：Made model with injecting D-galactose in abdominal cavity.Teat with piracetam, Yinchen WulingSan or Dihuang Yinzi respectively.Test malondialdehyde（MDA） and glutathione peroxidase（GSH-Px） in brain tissue.Results： Yinchen WulingSan and Dihuang Yinzi obviously degraded MDA and advanced GSH-Px.The latter had more obviouse action.Conclusion：The two prescriptions could improve brain tissue lipid peroxidation dimnification.