摘要
目的探讨18F-氟脱氧葡萄糖（18F-FDG）PET-CT与99Tc-亚甲基二膦酸盐（99Tc-MDP）全身骨显像对转移性骨肿瘤的诊断价值。方法93例经病理证实为恶性肿瘤的患者同时接受18F-FDGPET-CT和—99Tc-MDP全身骨显像（时间间隔在1周之内），对比分析两种显像结果，骨转移的诊断通过随访2年，由病理、X射线片、CT或MRI检查结果综合决定。结果93例恶性肿瘤患者中，经过2年随访或病理证实骨转移44例，其中18F-FDGPET-CT灵敏度、特异度和准确率分别为95．4％、91．8％和93．5％，99Tc-MDP全身骨显像分别为90．9％、63．3％和76．3％。18F-FDGPET．CT对转移性骨肿瘤诊断的灵敏度与99Tc-MDP全身骨显像相近，但特异度（t=2．53，P〈0．05）和准确率（t=2．47，P〈0.05）均明显高于99Tc-MDP全身骨显像。结论PET-CT对转移性骨肿瘤有较高的诊断价值。
Objective To investigate the diagnostic value of 18F-fluorodeoxyglucose PET-CT and 99Tc- methylene phosphonate whole body imaging in detection bone metastases. Methods lSF-FDG PET-CT and 99Tc-MDP whole body bone scan were both performed in 93 patients with malignant tumors testified by pathology. Bone metastases were confirmed by pathology, X ray or CT or MRI and follow-up for not less than 2 years. Results Of the 93 patients 44 were confirmed to have bone metastases by 2 years follow-up or pathology. The sensitivity, specificity and accuracy of lSF-FDG PET-CT were 95.4%, 91.8%, 93.5%, and 99tc-MDP bone imaging were 90.9%, 63.3%, 76.3%, respectively, 18F-FDG PET-CT has a better specificity （t=2.53, P〈0.05） and accuracy （t=2.47, P〈0.05） in detecting bone metastases than that of 99Tc-MDP bone imaging. Conclusion PET-CT is a more valuable method in the diagnosis of bone metastases.
出处
《国际放射医学核医学杂志》
2008年第3期147-150,共4页
International Journal of Radiation Medicine and Nuclear Medicine
