不同海拔地区部分正常人血管收缩及舒张物质的测定分析

The assay of angiotonin and angiodiactin by testing people in different altitudes

目的了解不同海拔地区部分正常人血浆内皮肽（ET）、降钙素基因相关肽（CGRP）和肾上腺髓质素（ADM）浓度变化，探讨其在低氧状态下对正常人生理的影响。方法不同海拔地区的正常人均抽空腹晨血注入到抗凝管内，分离血浆后采用放射免疫法分别测定ET、CGRP和ADM的水平。结果中度海拔地区与低海拔地区正常人ET及ADM有显著性差异（q=3．60，q=5．89，P〈0．01），而CGRP无显著性差异；高海拔地区与中度海拔及低海拔地区比较三项测定均有显著性差异。结论高海拔地区正常人血浆ET和CGRP均与ADM呈负相关，提示二者可能与ADM构成一个平衡系统，它们共同在生理过程中发挥重要作用；高海拔地区ADM的增高也可能是机体的一种自我保护和自我平衡的反应。

Objective The concentrations of endothelin （ET）, Calcitonin generelated （CGRP） and adrenc medulla（ADM） in blood can be affected in different altitudes. The aim of this study was to find out these variations and how ET, CGRP and ADM to contribute the physiology of human in the hypoxia status. Methods The samples which were stored in the special anticoagulation tubes were collected in different altitudes by phlebotomizing the health adult in the morning who were told to keep empty stomach. After separating the plasma, the ET, CGRP and ADM were measured by radioimmunity assay. Results The concentration of ADM and ET in the health adult had significant deviation statistically between the midrange altitude and low altitude area（q=3.60, q=5.89, P〈0.01）. Though the CGRP were not. There was significant deviation statistically in all three indices for the high altitude area when compared with the midrange and low altitude area. Conclusions In the high altitude area, the ET and CGRP level in health adult＇s blood all had the negative correlation with the ADM. It may indicate these three vasoactive substance coordinate with each other and play an important role in the hypoxia state. The level of ADM in blood increasing may be the reaction of the body protection and self-balance.