妊娠期高血压疾病血钙水平与血液流变学指标的相关性

Investigation of correlation between the levels of blood calcium and index of hemorheology in patients with pregnancy induced hypertension

目的:分析妊娠期高血压疾病患者血钙与血液流变学指标的变化,探讨血钙与血液粘度之间的相关性。方法:采用病例对照研究方法,选取90例妊娠期高血压疾病患者为妊娠期高血压疾病组,其中包括妊娠期高血压22例、子痫前期68例(子痫前期轻度38例、子痫前期重度30例);46例正常晚孕妇女为正常晚孕组;38例非孕健康妇女为对照组。比较3组血钙及血液粘度水平差异,同时分析妊娠期高血压疾病血钙及血液粘度之间的相关性。结果:妊娠期高血压疾病患者与正常晚孕妇女相比,血钙水平显著降低,血液粘度明显升高,差异有显著性(P<0.01)。妊娠期高血压疾病患者血钙水平与全血高、中、低切粘度及血浆粘度均呈显著负相关关系,Spearman等级相关系数分别为-0.698、-0.723、-0.776和-0.824,P<0.01。结论:妊娠期高血压疾病血钙及血液粘度存在着明显的异常变化,且血钙及血液粘度之间存在着负相关性。

Objective： To analyze the changes of blood calcium and index of hemorheology in patients with pregnancy induced hypertension （PIH） and to investigate their correlation. Methods ： A case - control study was used for determining the levels of blood calcium and blood viscosity in 174 cases. Correlation analysis of them was maded. Results： The blood calcium level was decreased significantly and blood viscosity levels was increased significantly in PIH patients. There was significant difference among the three groups, there was negative correlation between the wholeblood viscosity at low, medium and high shear and blood calcium in PIH patients, their correlation coefficients were - 0. 698, -0. 723, - 0. 77 and - 0. 824, respectively. Conclusion： There are great changes between the levels of blood calcium and blood viscosity in PIH, presenting negative correlation.