活体基因转染的物理方法
摘要
基因治疗是具有良好前景的疾病治疗手段，安全高效的载体是基因治疗的关键。一般来说基因治疗的载体分为两类：病毒载体和非病毒载体。常用的病毒载体包括逆转录病毒和腺病毒，它们转染效率高；但也有不利的一面，例如病毒毒性、宿主免疫排斥、制备困难等。相对而言，质粒是相对较为安全的载体，它不整合入基因组，免疫原性低，易于大量制备，
出处
《组织工程与重建外科杂志》
2008年第4期238-240,共3页
Journal of Tissue Engineering and Reconstructive Surgery
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