转化生长因子β与腭裂发生的研究进展

Transforming growth factor β and cleft palate

腭裂是人类常见的先天性畸形,研究显示多种细胞因子及其受体在腭发育中起着重要的作用,研究这些细胞因子及其信号通路为腭裂病因学的探索提供了一个重要线索,其中转化生长因子β(TGFβ)及其受体受到了广泛的关注。本文就TGFβ及其受体的结构和功能、TGFβ信号通路及其与腭裂的相关性研究作一综述。

Cleft palate is one of the most common congenital malformations. Many growth factors have been reported in which their receptors were involved in palatogenesis. These reported researches about growth factors and their signaling pathways contribute to a better understanding of the etiopathogenesis of cleft palate. Transforming growth factor β （TGFβ） is considered as the most valuable one involved in cleft palate among these growth factors. The structure and the function of TGFβ with its receptors, signaling pathways and in particularly, its relationship with cleft palate were summarized in this review.