摘要
5-氨基-1-羟乙基吡唑是第四代硫酸头孢噻利的C-3位侧链,研究其合成路线并进行优化对降低硫酸头孢噻利成本具有重要的意义。分析了其反应机理、影响反应的各种因素,优化后的合成条件为:反应温度90℃,n(β-羟乙基肼)∶n(3-甲氧基丙烯腈)=2∶1。此条件下产品纯度95.1%,收率53.1%。产品用质谱、核磁共振进行了表征。
5-Amino-1- hydroxyethylpyrazole is the C-3 side-chain of cefoselis sulfate. The optimization of its synthesis route is important in reducing the cost of eefoselis sulfate. Through analysis the reaction mechanism and influential factors, it was found that the optimial reaction condition is that the temperature was 90℃ and the mole ratio of 2- hydrazzinoethaoland 3-methoxyaerylonitrile was 2 ： 1.
出处
《精细化工中间体》
CAS
2008年第4期28-30,共3页
Fine Chemical Intermediates
基金
湖南省科技攻关项目(2007FJ3052)
长沙理工大学基金资助项目
