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优生干预对染色体平衡易位携带者再次妊娠结局的影响

The Effect of Eugenism Intervention on Re-pregnancy of Patients with Chromosome Balanced Translocation
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摘要 目的探讨优生干预对染色体平衡易位携带者再次妊娠结局的影响。方法对22例染色体平衡易位携带者再次孕前行血清生殖激素水平测定、免疫抗体检测及生殖道炎症检查后,于患者再孕前后分别进行优生干预性治疗并行产前诊断。结果15例患者再次成功妊娠,其中13例(68.2%)已分娩表型正常儿,子代染色体不平衡异常率仅为31.8%,明显低于理论异常率(60%~80%)。结论优生干预可显著提高染色体平衡易位携带者再次妊娠的优生率。 Objective To evaluate the effect of eugenism intervention on re-pregnancy of patients with chromosome balanced translocation. Methods The blood reproductive hormone, immune antibody and genital tract inflammation of 22 patients with chromosome balanced translocation were detected before re-pregnancy. The patients were treated with birth-defect prevention before and after pregnancy, and were received prenatal diagnosis. Results Thirteen babies among 15 patients with re-pregnancy were normal( 68.2% ) , and the abnormal rate of babies was otdy 31.8% ,which was much lower than the academic abnormal rate ( 60% - 80% ). Conclusion Eeugenism intervention can remarkablely increase the eugenism rate of re-pregnancy in patients with chromosome balanced translocation.
出处 《潍坊医学院学报》 2008年第3期242-243,共2页 Acta Academiae Medicinae Weifang
关键词 染色体 平衡易位 优生 干预措施 Chromosome Balanced translocation Eugenism Intervention
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参考文献6

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  • 1张严华,第四军医大学学报,1989年,10卷,1期,43页
  • 2顾美礼,实用妇产科杂志,1988年,4卷,83页
  • 3杨燕生,国外医学妇产科学分册,1987年,14卷,87页

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