含锌碳磷灰石的溶胶凝胶法制备及性能表征

The preparation and characterization of sol-gel derived zinc modified carbonated hydroxyapatite

目的通过溶胶凝胶法制备含锌的碳磷灰石(Zn-CHA)涂层材料,并探讨锌离子取代反应对羟磷灰石物理化学性质的影响。方法实验制备了锌离子取代量和钙磷比不相同的两组样本,其中钙足量组样本的钙磷比为1.67,锌离子取代4%的钙离子;钙不足量组的钙磷比小于1.67,锌离子取代8%的钙离子。采用X射线衍射仪(XRD)、傅立叶变换红外光谱仪(FTIR)对样本的物相结构和化学组成进行分析研究,并采用扫描电镜观察样本的表面形貌。此外,还采用原子吸收分光光度计(AAS)对样本的溶解特性与锌离子的关系进行研究。结果X射线衍射分析表明样本中含有羟磷灰石相,傅立叶变换红外光谱分析结果表明样本为碳磷灰石,溶解实验表明钙不足量组和钙足量组样本中分别存在锌离子整合到羟磷灰石晶格内和吸附在羟磷灰石晶体表面两种情况。结论研究表明含锌的碳磷灰石能够通过简单的溶胶凝胶法制备获得。

Objective To prepare zinc-modified carbonated hydroxyapatite （Zn-CHA） coating material via sol-gel method and explore the influence of zinc substitution on physical and chemical properties of biomaterial samples. Methods Two kinds of samples with different zinc content and Ca/P molar ratio were prepared. One was fabricated with 4% zinc and the Ca/P molar ratio was 1.67. Another was prepared with 8% zinc and the （Ca＋Zn）/P molar ratio was 1.67. The coating samples were characterized by X-ray diffraction （XRD）, Fourier transformed infrared spectroscopy （FTIR）, scanning electron microscopy （SEM）. Furthermore, the zinc ions releasing ability of the coating samples were investigated by atomic absorption spectroscopy （AAS）. Results XRD results revealed that the coating samples contained hydroxyapatite phase. After determination by FTIR, the biomaterial samples were found to contain carbonate and resemble biological apatites. High homogeneous and porous surfaces of coating samples were observed in SEM micrographs. According to the results of dissolution test, zinc was incorporated into hydroxyapatite lattice structure or surface absorbed when calcium was insufficient or sufficient respectively. Conclusion The results demonstrate that phase-pure zinc-modified carbonated hydroxyapatite might be prepared through simple sol-gel method and have favorable antibacterial effect.