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核磷蛋白与肿瘤的发生 被引量：1

Nucleophosmin and cancer
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摘要 核磷蛋白(nucleophosmin,NPM)是一个具有多种功能的重要蛋白,定位于核仁,可在胞核与胞浆之间快速穿梭。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因。后来研究发现NPM也具有抑制肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关。这表明NPM的作用及其机制非常复杂,可能通过多种机制调控肿瘤的发生。 Nucleophosmin（NPM） is an essential multifunctional protein, which is localized in nucleolus and can shuttle rapidly between the nucleus and cytoplasm. NPM1 is frequently overexpressed in human cancer and regarded as a tumor marker and a proto-oncogene. Recent researches indicated that NPM1 has tumor-suppressor functions and its mutation, rearrangement and deletion are attributed to tumorigenesis. The function of NPM is very complicated and it is involved in oneogenesis through many mechanisms.
作者 徐诚望 杨晓明
机构地区 军事医学科学院放射与辐射医学研究所
出处 《军事医学科学院院刊》 CSCD 北大核心 2008年第4期382-385,共4页 Bulletin of the Academy of Military Medical Sciences
基金 国家自然科学基金资助项目(30570781)
关键词 核磷蛋白 肿瘤 P53 抑癌蛋白富精氨酸因子 肿瘤标记 生物学 癌基因 突变 nucleophosmin tumor p53 ARF tumor marker biological oncogene mutation
分类号 R730.2 [医药卫生—肿瘤]
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参考文献31

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同被引文献6

  • 1Simon L,Michael P,James C,et al.Genetics,molecular biology,neuropathology and phenotype of frontal lobe dementia:A case history[J].British Journal of Psychiatry,2002,180:455-460.
  • 2Nilsen LH,Mel TM,Saether O,et al.Altered neurochemical profile in the Mc Gill-R-Thy1-APP rat model of Alzheimer’s disease:a longitudinal in vivo 1H MRS study[J].J Neurochemistry,2012,123(4):532-541.
  • 3Rodrigues Elizabeth M,Weissmiller April M,Goldstein Lawrence SB,et al.Enhanced[beta]-secretase processing alters APP axonal transport and leads to axonal defects[J].Human Molecular Genetics,2012,21(21):4587-4601.
  • 4Dohner K,Schlenk RF,Hab dank M,et al.Mutant nucleophosmin(NPM1)predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics interaction with other gene mutations[J].Blood,2005,106(12):3740-3746.
  • 5Thathiah A,De Strooper B.The role of G protein-coupled receptors in the pathology of Alzheimer’s disease[J].Nature Reviews Neuroscience,2011,12(2):73-87.
  • 6Bromley B,Kelley S,Song Wei-hong,et al.The role of TMP21 in trafficking and amyloid-[beta]precursor protein(APP)processing in Alzheimer’s disease[J].Current Alzheimer Res,2012,9(4):411-424.

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军事医学科学院院刊
2008年 第4期

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