摘要
目的观察老年人脑内多巴胺转运体的表达。方法以免疫放射自显影技术显示人脑标本神经核团多巴胺转运体免疫反应强度的变化。结果老年组多巴胺转运体免疫反应强度较青年组明显降低;壳、尾状核、中脑黑质腹侧区和背侧区多巴胺转运体免疫反应强度较青年组分别降低了28.22%(P<0.01)、35.55%(P<0.01)、19.25%(P<0.05)和15.41%(P<0.05)。结论老年人黑质纹状体多巴胺转运体的低表达暗示其脑内多巴胺能神经体系的功能减退。
Objective To study the altered dopamine transporters （DAT） in postmortem aged human brains. Methods Immunoautoradiography was used to reveal DAT immunoreactive intensity in postmortem human brains. Results DAT immunoreactive intensity in aged human brains was lower than that of young group. 28. 22%, 35.55% , 19. 25% and 15.41% of DAT immunoreactive intensity significantly decreased DAT immunoreactive intensity in putamen, caudate nucleus, ventral and dorsal substantia nigra in aged group respectively decreased 28.22% （ P 〈 0. 01 ）, 35.55% （ P 〈 0. 01 ）, 19.25% （ P 〈 0. 05） and 15. 41% （ P 〈 0. 05 ） than those of corresponding sites in young group. Conclusions Decreased DAT expressions of nigrostriatal system in the aged human brains suggest the function decline of their cerebral dopamine neural system.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2008年第16期1607-1608,共2页
Chinese Journal of Gerontology
基金
河北省科学技术研究与发展指导课题(No.062761385)
河北省教育厅科学技术研究与发展指令性计划课题(No.2007129)
关键词
多巴胺转运体
免疫放射自显影
脑
Dopamine transporter
Immunoautoradiography
Human brain
