丙戊酸镁合并洛沙平治疗80例有精神病性症状躁狂发作的疗效观察

Treatment effect of magnesium valproate combination with loxapine for current episode manic with psychotic symptoms

目的:比较单一大剂量洛沙平与丙戊酸镁合并小剂量洛沙平治疗有精神病性症状的躁狂发作的疗效和安全性。方法:将80例有精神病性症状的躁狂发作患者随机分成两组,分别接受为期6周的治疗。结果:在第6周末,单用洛沙平治疗组患者的临床总有效率为92.5%;丙戊酸镁合并小剂量洛沙平组的临床总有效率为97.5%;单用洛沙平组和丙戊酸镁合并洛沙平组的不良反应发生率分别为70.0%和40.0%,差异有显著性。结论:丙戊酸镁合并小剂量洛沙平治疗有精神病性症状的躁狂发作临床疗效优于单一大剂量洛沙平治疗且不良反应相对减少。

Objective： To compare the treatment effect and safety of single big dosage loxapine and magnesium valproate combining little dosage loxapine to treat current episode manic with psychotic symptoms. Methods：80 patients that had current episode manic with psychotic symptoms are accidentally divided into two groups and differently treated for 6 weeks. Results： On end of 6th, efficiency of the group of patients using loxapine is 92.5% , and clinical efficiency of the group of patients using magnesium valproate and little dosage loxapine is 97.5%. Side effect occurring rate of the group using loxapine is 70.0%. Side effect occurring rate of the group using magnesium valproate and loxapine is 40.0%. The difference is remarkable. Conclusions： Treatment effect of magnesium valproate and little dosage loxapine to treat current episode manic with psychotic symptoms is better than single big dosage loxapine. Side effect is relatively reduced.