奎硫平与舒必利治疗精神分裂症对照研究

A Control-study between Quetiapine and Sulpiride in the Treatment of Schizophrenia

目的:比较奎硫平与舒必利治疗精神分裂症的临床疗效及安全性,为精神分裂症的治疗积累经验。方法:对74例精神分裂症患者随机分组治疗,研究组(完成35例)予奎硫平治疗,平均剂量为(712.4±151.3)mg/d,对照组(完成34例)予舒必利治疗,平均剂量(661.3±210.5)mg/d。观察8周。两组于治疗前及治疗第2、4、8周分别评定阳性与阴性症状量表(PANSS)及副反应量表(TESS)。结果:研究组第4周和第8周的PANSS总分及减分率与对照组差异无显著性(P>0.05),两组疗效相当(P>0.05)。但研究组显效较快,不良反应较少(P<0.05)。结论:奎硫平治疗精神分裂症疗效与舒必利相当,但起效较早且不良反应少。

Objective：To compare the efficacy and safety of quetiapine and sulpiride in the treatment of schizophrenia, so as to accumulate experiences for treating schizophrenia. Methods： Totally 74 cases with schizophrenia were randomly divided into two groups. The study group were finished 35 cases treated with quetiapine of mean dose （712.4 ±151.3 ） mg/d and the control group were finished 34 cases receiving sulpiride of mean dose （661.3 ±210.5 ） mg/d. Each group were observated for 8 weeks. The Positive and Negative Symptom Scale （PANSS） and Treatment Emergent Symptom Scale （TESS） were used to measure efficacy and safety before treatment and at the 2nd ,4th ,8th week of treatment. Results： There showed no significant difference between the two groups in PANSS total scores and reducing score rates at the 4th and 8th week（ P 〉0.05 ）. The efficacy also showed no significant difference between the two groups（ P 〉 0.05 ）. But, the study group showed earlier curative effects and lower side - effect rate（ P 〈 0.05 ）. Conclusions ： Quetiapine is as effective and safe as sulpiride for the treatment of schizophrenia and has earlier curative effects and fewer side effects.