低分子肝素钠联合阿司匹林治疗老年不稳定型心绞痛的疗效分析

Analyzing the Effect of LMWH-Na Combined with Aspirin in Treating UAP foraged People

目的:观察低分子肝素钠联合阿司匹林治疗老年不稳定型心绞痛(UAP)的有效性和安全性。方法:102例老年UAP患者在应用心绞痛常规治疗的基础上随机分为阿司匹林组(对照组,50例),联合低分子肝素钠皮下注射组(治疗组,52例),疗程均为10d,观察治疗前后临床症状、ECG及出血不良反应的改变。结果:治疗10d后,治疗组心绞痛缓解及ECG的改善均明显优于对照组,两组间比较有显著性差异(P<0.01)。对照组治疗后有4例牙龈出血,无严重出血病例,治疗组治疗后有10例出现注射部位皮下淤斑,有2例出现严重出血不良反应(P<0.05)。结论:低分子肝素钠联合阿司匹林治疗老年UAP疗效显著,但也增加了出血的不良反应,因此在使用低分子肝素钠联合阿司匹林治疗老年UAP的过程中需密切注意出血的不良反应。

Objective： To observe the effectiveness and security of using LMWH - Na combined with as- pirin in treating UAP for aged people. Method： Based on the normal treatment applied in angina, we sepa- rated 102 aged- people UAP cases into 2 groups, one was only using aspirin { contrast group, 50 cases）, the other was using aspirin combined with LMWH - Na to treat （ treating group, 52 eases ）. The treatment period was 10 days, and changed on the clinical symptoms before and after treatment, ECG and untoward effect were observed. Result： After 10 days, the treating than that of the contrast group. The contrast was obvious group＇ s ECG result and angina was much better （ P 〈 O. O1 ）. After treatment, the contrast group had 4 cases of gum bleeding, and none of them with serious bleeding. The treating group had 10 cases of en- dermic eeehymosis in injection site, 2 of them had serious untoward effect of bleeding { P 〈 0.05 ）. Conclu- sion： Using LMWH - Na combined with aspirin to treat UAP for aged people has obvious positive effect, how- ever, it increased the untoward effect of bleeding. Therefore, it＇ s necessary to closely observe the untoward effect of bleeding during the treatment on UAP for aged people by using LMWH - Na combined with aspirin.