摘要
PEO-PPO-PEO嵌段共聚物是重要的非离子型高分子表面活性剂,在药物载体和基因治疗等领域有着广阔的应用前景.核磁共振(NMR)作为重要的研究手段,在研究PEO-PPO-PEO嵌段共聚物胶团及液晶结构形成,揭示嵌段共聚物与各种添加剂或药物分子的相互作用机理,有着独特的优势.本文重点介绍了1H、13C和2H NMR波谱以及NMR弛豫时间和自扩散NMR等技术在研究PEO-PPO-PEO嵌段共聚物体系中的应用.简要介绍了NMR技术在PEO-PPO-PEO嵌段共聚物聚集、调控以及作为药物载体等方面的研究现状.
Recent NMR studies on aggregation and modulation of PEO-PPO-PEO block copolymer in aqueous solution are reviewed. Because of the unique advantages of the NMR techniques, ^1H-, ^13C- and ^2H NMR, as well as NMR-based relaxation and diffusion measurements, have been widely used for studying the aggregation and interaction of PEO-PPO-PEO block copolymer in complex systems. The results of many research groups, including our own, have indicated that modulation of the properties of PEO-PPO-PEO block copolymer in solution plays the most important role in the applications of this compound.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2008年第3期421-434,共14页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金资助项目(20221603,20490200and20676137)
863项目基金资助(20060102Z2049)
