奥扎格雷钠治疗急性缺血性脑血管病52例临床观察

Clinical Observations on Therapeutic Effect and Safty of Ozagrel in the Treatment of Ischemic Cerebral Disease

目的观察奥扎格雷钠治疗急性缺血性脑血管病的疗效。方法脑梗死患者52例,将注射用奥扎格雷钠80mg溶于5%葡萄糖注射液或0.9%氯化钠溶液500ml中静脉滴注,1日2次,2周为1个疗程,根据统一制定的卒中患者临床神经功能缺损程度评分标准评定治疗效果,并进行统计学处理。结果52例患者中,基本痊愈19例(36.5%),显著进步21例(40.4%),进步8例(15.4%),总有效率92.3%。不良反应少。结论奥扎格雷钠为治疗缺血性脑血管病安全有效的药物。

Objective To observe the effect and safty of ozagrel in the treatment of ischemic cerebrovascular disease. Methods Fifty-two cases of cerebral infarction, who were confirmed by craniocerebral CT or MRI, were treated with 80mg ozagrel in 500 ml 5% glucose solution （or 0.9% sodium chloride solution） by intravenous drip bid, The course of treatment lasted 2 weeks.According to ＂standard marking of clinical nervous function defects in apoplexy patients＂, the curative effect was evaluated and the results were under analysis stalistically. Results Ozagrel had significart effect in treatment of ischemic cerebrovascular disease;19 cases （36.5%） of cerebral infarction were bastic mend, 21 cases （40.4%） of cerebral infarction were relieved greatly and 8 cases （15.4%） improved.The total effective rate was 92.3 %, and adverse reaction mild. Conclusion These results suggest that ozagrel is an effective and safe drug in the treatment of ischemic cerebrovascular disease.