原发于睾丸和纵隔生殖细胞恶性肿瘤预后因素分析

Prognostic Factors in Testicular and Mediastinum Primary Germ Cell Tumor

[目的]探讨原发于睾丸和纵隔生殖细胞恶性肿瘤的临床特征、生存率及预后影响因素。[方法]回顾性分析1990至2000年收治的22例原发于睾丸和19例原发于纵隔的生殖细胞肿瘤患者的临床资料,以无疾病进展时间和总生存率为主要观察目标,进行预后评估。[结果]睾丸和纵隔生殖细胞肿瘤患者无疾病进展时间分别为62个月和19个月,10年总生存率分别为60.0%和13.3%(P=0.019)。Cox比例风险模型多因素分析结果显示:病理类型和临床分期是影响预后的主要因素。[结论]睾丸生殖细胞瘤患者的预后明显高于纵隔生殖细胞瘤患者,需要进一步探讨如何提高纵隔生殖细胞瘤的治疗效果。

[ Purpose ] To study the clinical characteristics, overall survival and prognostic factors in testicular and mediastinum primary germ cell tumor. [Methods] The dinical data from 1990 to 2000 were retrospectively reviewed, including 22 cases with primary testicular germ cell tumor and 19 cases with primary mediastinum germ cell tumor. Progression free survival （PFS） and overall survival （OS） were the primary objectives to assess prognosis. [Results] For testicular germ cell tumor and mediastinum germ cell tumor, the PFS was 62 months and 19 months; 10 years＇ OS, 60.0% and 13.3%, respectively, P=0.019. Cox model multivariate analysis indicated that the pathologic type and staging were closely associated with prognosis. [Conclusion] Prognosis of primary testicular germ cell tumor is much better than that of mediastinum germ cell tumor. Improving the treatment efficacy of mediastinum germ cell tumor still need further study.