自体心包作为主动脉瓣替代材料的可行性研究

A FEASIBILITY STUDY OF AUTOLOGOUS PERICARDIUM AS AORTIC VALVE SUBSTITUTE

目的探讨自体心包组织作为主动脉瓣膜替代材料的可行性及可靠性,为临床实验提供基础。方法静脉全麻、腹主动脉阻断下行心包瓣膜材料腹主动脉内移植。进行预试验,筛选实验动物。然后监测实验中动物基本生命、生理指标;采用血管超声和CTA方法评价其血流动力学指标;通过观察动物存活情况,判断是否有栓塞事件等,以评价其生物相容性。结果猪是理想的实验动物,手术死亡率6.25%。实验动物无栓塞事件发生,肉眼观察可见心包瓣内有血栓形成。结论腹主动脉阻断下心包瓣膜移植,手术安全易行,心包瓣膜模型较为可靠。建议术后应常规抗凝。

Objective To study the feasibility and reliability of autologous pericardium to be uesd as aortic valve replacement. Methods An abdominal aorta replacement by using pericardium was done under general anesthesia. A preliminary test was conducted to screen experimental animals. The vital signs and physiological index were monitored. Hemodynamics was evaluated by vascular ultrasonography. The survival of the animals was observed to judge if there was any embolisims so as to assess the biocompatibility. Results A pig was an ideal experimental animal. The operative mortality was 6. 25 %. No embolism was noted. Thrombogenesis in pericardial valve was seen on macroscopic observation. Conclusion Pericardial valve implantation done under abdominal aorta blocking is safe and easy. Post-operative anticoagulant therapy is advisable.