高良姜超临界萃取物对应激性溃疡模型大鼠溃疡形成和胃液分泌及生长抑素水平的影响

Effect of extraction from rhizoma alpiniae officinarum by CO_2 SFE on ulcer index and gastric secretion and somatostatin about stress ulcer

目的探讨高良姜超临界萃取物(GLJ)对应激性胃溃疡模型溃疡形成及胃液分泌、血清胃泌素(GAS)和胃黏膜生长抑素(SS)的影响。方法以束缚-水浸应激性胃溃疡大鼠为对象,探讨GLJ对大鼠溃疡指数及胃液分泌、胃蛋白酶活性、血清胃泌素(GAS)和胃黏膜生长抑素(SS)水平的影响。结果GLJ能降低束缚-水浸应激性溃疡大鼠的溃疡指数,并可使该模型大鼠胃液分泌量、血清GAS水平和胃蛋白酶活性降低,胃黏膜SS水平明显回升,接近正常水平。结论GLJ能降低束缚-水浸应激性胃溃疡的形成,对此模型胃液分泌、血清GAS、胃黏膜SS水平有一定的调节功能,可能是其抗溃疡作用的机制之一。

Aim To study effect of extraction from rhizoma alpiniae officinarum by CO2 SFE （GLJ）on helcosis, gastric secretion gastrin （GAS） and somatostatin（SS） about stress ulcer. Methods Experimental gastric ulcer rats were molded by cold restraint-stress, then the effect of GLJ on ulcer index,pepsin activity, gastric secretion and SS level in gastric mucosa was observed. Results GLJ can reduce the ulcer index in stress ulcer rats, decrease the secretion of gastric mucus and pepsin activity,increase the level of SS in gastric mucosa. Conclusion It indicated that adjusting the secretion of gastric mucus, GAS and SS may be one of the mechanism of GLJ anti-ulcer.