三氧化二砷联合全反式维甲酸治疗急性早幼粒细胞白血病29例

Treatment of acute promyelycytic leukemia with combination of all-trans retinoic acid and arsenic trioxide:a report of 29 cases

目的观察三氧化二砷(As2O3)联合全反式维甲酸(ATRA)治疗急性早幼粒细胞白血病(APL)的疗效及毒副反应。方法患者使用三氧化二砷联合全反式维甲酸双诱导治疗,对高白细胞患者加用单一化疗药物高三尖衫酯碱(H)或柔红霉素(DNR),合并弥漫性血管内凝血(DIC)患者予以输注血浆/纤维蛋白原。结果29例患者中26例完全缓解,完全缓解(CR)率89.66%;3例死于颅内出血。结论三氧化二砷联合全反式维甲酸治疗急性早幼粒细胞白血病的疗效确切,患者耐受性较好。

Aim To observe the therapeutic effects and side effects of combination of all-trans retinoic acid and arsenic trioxide for treating acute promyelycytic leukemia. Methods All the patients received all-trans retinoic acid and arsenic trioxide. Homoharringtonine or daunorubicin was given if the white blood cells were high, and plasme or fibrinogen transfusions were given if disseminated intravascular coagulation happened, Results Among all the 29 cases,26 cases（89.66% ） achieved complete remission,while 3 cases died of encephalic bleeding. Conclusion The therapeutic effects of all-trans retinoic acid combined with arsenic trioxide for acute promyelycytic leukemia were good.