摘要
目的:制备苦参碱微乳透皮给药系统,对其理化性质及透皮行为进行考察。方法:以苦参碱、磷脂、聚氧乙烯辛基苯基醚、肉豆蔻酸异丙酯和去离子水为主要成分,水相溶液逐滴加入油相的方法,制备苦参碱微乳,考察其外观形态、粒径大小及分布,采用Valia-Chien扩散池考察苦参碱微乳的体外透皮过程。结果:制得的苦参碱微乳为淡黄色透明液体,平均粒径120 nm,外观圆整均匀,24 h的累积释放量为(1 056.1±74.9)μg/cm2。结论:苦参碱微乳具有良好的透皮效果,为苦参碱的临床应用提供了一种新型制剂。
Objective： To prepare matrine loaded microemulsion as transdermal delivery system and study its physicochemical properties and skin permeability. Methods： Traditional water dropwise titration method was adopted to prepare microemulsion using matrine, phospholipid, Triton X-100 （OP） ,isopropyl myristate and deionized water as main ingredients. The morphology and grain size distribution of microemulsion were studied. Skin permeability test was performed using Valia-Chien cell. Results：The microemulsion was yellow in color and its grains were round,with mean grain size at 120 nm in diameter. Cumulative permeation quantity in 24 h was （1 056.1 ± 74.9） μg/cm^2. Conclusion： Matrine loaded microemulsion has good permeability. It is a practical preparation of matrine for clinical use.
出处
《药学服务与研究》
CAS
CSCD
2008年第4期252-254,共3页
Pharmaceutical Care and Research
关键词
苦参碱
微乳
投药
皮肤
制备
matrine
microemulsion
administration, cutaneous
preparation
