抗环瓜氨酸肽抗体联合类风湿因子诊断类风湿性关节炎

The diagnostic value of combined detection of anti-CCP antibody and rheumatoid factor in patients with rheumatoid arthritis

目的探讨抗环瓜氨酸肽抗体(抗-CCP)和类风湿因子(RF)联合检测对类风湿性关节炎(RA)的诊断价值。方法抗-CCP采用酶联免疫吸附试验法定量检测,RF采用速率散射免疫比浊法检测。结果83例RA患者抗-CCP阳性52例,阳性率62.7%,RF阳性59例,阳性率71.7%,126例非RA患者抗-CCP阳性2例,阳性率1.6%,RF阳性23例,阳性率18.3%,抗-CCP对RA诊断的灵敏度为60.8%,特异性为93.7%;RF对RA诊断的灵敏度为69.2%,特异性为78.5%,二者联合检测时特异性达到99.7%。结论抗-CCP对RA的诊断有良好的灵敏度和特异性,比RF更具特异性,二者联合检测可极大地提高对RA诊断的准确性。

Objective To explore the clinical value of the combined detection of anti-cyclic citrullinated peptide （anti-CCP） antibody and rheumatoid factor （RF） in the diagnosis of rheumatoid arthritis （RA）. Methods Anti-CCP antibody was measured with ELISA and RF with rate scatting immunoturbidimetry assay. Results In 83 patients with RA, 52 cases （62.7%） were anti-CCP antibody positive and 59 cases （71.7%） were RF positive; while in 126 non-RA patients, 2 cases （1.6%） were anti-CCP antibody positive, 23 cases （18.3%） were RF positive. The sensitivity and specificity of anti-CCP antibody for the diagnosis of RA was 60.8% and 93.7% respectively, while the sensitivity and specificity of RF was 69.2% and 78.5% respectively. The sensitivity of combined detection of anti- CCP antibody and RF accounted for 99.7%. Conclusion The sensitivity and specificity of anti-CCP antibody are satisfactory in diagnosis of RA. Anti-CCP antibody is more specific than RF. Combined detection of anti-CCP antibody and RF improves the accuracy of RA diagnosis greatly.