条件化恐惧消退的神经机制研究进展

Research Progress on Neural Mechanisms of Conditioned Fear Extinction

经典恐惧条件化是研究情绪学习记忆的重要动物模型;条件化恐惧消退是一主动的、新的学习过程而非原有恐惧记忆的简单遗忘.目前,对于恐惧消退神经机制的了解还远滞后于恐惧条件化本身.本文综述了近年来条件化恐惧消退神经机制研究的主要成果,重点对前额叶与杏仁核在恐惧消退中的作用进行了讨论.

Classical fear conditioning is regarded as an important animal model to study emotional learning and memory. Extinction of conditioned fear is thought to involve the formation of new memory rather than erase fear conditioning. Up to date,research on the mechanism of fear extinction has lagged behind that of fear conditioning. In the article, we review research progress on the neural basis of fear extinction is generalized and discussed, with a focus on the role of the prefrontal cortex and the amygdala.