西酞普兰与氟西汀治疗精神病后抑郁及残留期抑郁的对比研究

Comparative study on the treatment of postpsychotic depression and residual period depression between citalopram and fluoxetine

目的:探讨精神分裂症患者在精神病后抑郁及残留期抑郁使用西酞普兰(喜普妙)与氟西汀疗效的对比。方法:将60例精神分裂症患者随机分为两组,分别以西酞普兰和氟西汀治疗,疗程4周,采用汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗4周以后,两组患者HAMD评分均显著减少(P<0.05或P<0.01),TESS评分均未见明显增加。两组间比较HAMD,TESS评分差异无显著性(P>0.05)。结论:西酞普兰与氟西汀在治疗精神分裂症患者精神病后抑郁及残留期抑郁表现均有较好的疗效,不良反应较少,但西酞普兰组在减少复发及多药合用等方面较氟西汀有一定优势。

Objective ：To compare the effection of citalopram and fluoxetine treatment in postpsychotic depression and residual period depression. Methods：60 patients with schizophrenia were randomly assigned to citalopram group and fluoxetine group for four weeks. The clinical efficacy was evaluated by Hamilton rating scale for depression （HAMD） and the adverse effects were estimated by treatment emergent symptoms scale （TESS）. Results：At end of treatment for four weeks,Both before and after treatment of the two groups had a very significant difference （P〈0.05 or P〈0.01 ）in HAMD. The effection between the groups had no significant （P〉0.05）. Grading in TESS has not seen increases obviously. At same time, the adverse effect between two groups had no significance（P〉0.05）. Conclusion：Citalopram and fluoxetine have the good curative effect in treating despondent symptom of postpsychotic depression and residual period depression. The adverse effect in the groups were fewer. But there was a certain superiority in reducing recrudescence and the multi-medicines coming in handy in citalopram group.