异位ACTH综合征患者糖代谢异常的特点分析

Analysis of glucose dysbolism in patients with ectopic ACTH syndrome

通过对经病理证实的117例库欣综合征患者临床资料的分析，探讨异位ACTH综合征（EAS）糖代谢异常的特点。117例患者分为3组：EAS组9例，库欣病组（CD）67例，肾上腺皮质腺瘤组（AA）41例。与CD组和AA组相比，EAS组继发性糖尿病发生率高，血糖水平高，HbA1C水平低，原发病灶根治术后，血糖降至正常。

The characteristics of glucose dysbolism in ectopic ACTH syndrome （EAS） were investigated by analysing the clinical data of 117 patients with Cushing syndrome （CS）. The patients with CS were divided into 3 groups： EAS group （ n = 9）, Cushing＇s disease （CD） group （ n = 67） and adrenocortical adenoma （AA） group （ n = 41 ）. Retrospective analysis of the data covered the prevalence of secondary diabetes, blood glucose, HbA,c, blood potassium, and blood ACTH and 24 h urinary-free cortiso｜ （UFC） levels. Compared with CD and AA groups, the prevalence of secondary diabetes and blood glucose level were higher in EAS group, while HbA1c level was lower. Blood glucose level in patients with ectopic ACTH syndrome decreased to normal after tumor removal.