摘要
目的:探讨输卵管积水对人子宫内膜着床窗期的影响。方法:用免疫组化法检测输卵管积水组(A组)、输卵管阻塞无积水组(B组)和正常组(C组)着床窗期子宫内膜人白血病抑制因子(LIF)和转化生长因子(TGF)-β2的表达。结果:LIF和TGF-β2在3组着床窗期子宫内膜都有表达,A组的LIF和TGF-β2表达均明显低于B组和C组组(P<0.05)。结论:输卵管积水妇女着床窗期子宫内膜LIF和TGF-β2的低表达可能是输卵管积水妇女胚胎种植失败的原因之一。
Objective： To investigate the effect of hydrosalpinx on the expressions of LIF and TGF- β2 in the endometrium at implantation window. Methods： The expression of LIF and TGF-β2 at implantation window in the endometrium of women with hydrosalpinx and tubal occlusion and fertile women was examined by immunohistochemical method. Results： LIF and TGF-β2 expressed in the endometrium at implantation window. The expressions of LIF and TGF-β2 in the endometrium at implantation window of women with hydrosalpinx were significant lower than those of women with tubal occlusion but without hydrosalpinx and fertile women （P〈0.05）. Conclusion： The decreased expression of LIF and TGF-β2 in the endometrium at implantation window from women with hydrosalpinx may the one of the reasons why embryo implantation failed.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2008年第8期491-495,共5页
Reproduction and Contraception
