生石膏对致热原作用下猫PO/AH温敏神经元放电的影响

EFFECTS OF GYPSUM ON THE FIRING OF PYROGEN-TREATED THERMOSENSITIVE NEURONS IN PO/AH OF CATS

目的:研究中药生石膏解热作用的中枢机制。方法:复制发热模型后,静脉注射生石膏,应用微电极细胞外记录技术记录视前区-下丘脑前部(PO/AH)温敏神经元单位放电的变化情况。结果:给予致热原后,PO/AH区热敏神经元放电频率显著减少(P<0.01),冷敏神经元放电频率明显增加(P<0.05);静脉注射生石膏后,可反转致热原对PO/AH区温敏神经元的上述作用,与给药前相比,热敏神经元放电频率明显回升(P<0.01),冷敏神经元放电频率明显回降(P<0.05)。结论:提示生石膏是通过影响致热原作用下PO/AH区温敏神经元的放电活动,在中枢神经元水平上发挥解热作用的。

Aim： To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum. Methods： Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus（PO/AH） region was recorded by using extracellular microelectrode technique. Results： The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum. Conclusion： The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.