蜂贝化瘀胶囊治疗2型糖尿病视网膜病变的研究

Study on treatment of retinopathy in patients with Type 2 Diabetes Mellitus by Fengbei Huayu Capsule

目的探讨蜂贝化瘀胶囊治疗2型糖尿病视网膜病变的临床疗效。方法将63例患者分为3组。中药治疗组24例服用蜂贝化瘀胶囊,中药对照组22例服用参芪降糖颗粒,西药对照组17例服用降糖西药。观察患者眼底、血糖、糖化血红蛋白、血脂、胰岛素、丙二醛等指标的变化。结果中药治疗组眼底病变有明显好转,有效率为75%,中药对照组为68%,西药对照组为59%;中药治疗组血糖、糖化血红蛋白、胆固醇、丙二醛含量有明显下降(P均<0.05),与两对照组比较有显著性差异(P均<0.05)。结论蜂贝化瘀胶囊治疗2型糖尿病视网膜病变疗效肯定。其在改善眼底病变、降低血糖、抑制脂蛋白非酶基糖化、改善血脂方面均具有较好的疗效。

Objective It is to approach the clinical effect of Fengbei Huayu Capsule on treating retinopathy in patients with Type 2 Diabetes Mellitus （T2DM）. Methods 63 patients with T2DM were randomly divided into three groups. Treatment group （group A） contained 24 cases and taken Fengbei Huayu Capsule, traditional Chinese drug control group （group B） contained 22 cases and taken Shenqi Jiangtang Granule, Western medicine control group （group C） contained 17 cases and taken Captopril. The indexes such as eyeground changes, blood glucose （BG）, glycosylated hemoglobin （BH）, blootfat, insulin and MDA were observed after treatment for 10 weeks. Results The eyeground pathological changes in A group had obvious improvement. The general effective rate in group A was 75 % , and was 68 % in group B, and was 59 % in group C. The leves of BG, BH, bloot-fat and MDA in group A were significantly lower than the other groups （P〈0.05）, Conclusion Fengbei Huayu Capsule has the positive effect on the therapy of retinopathy in patients with T2DM. It has safe and better treating effects in improving the retinopathy, reducing BG and blood-fat and inhibiting lipoprotein nonenzymatic glycosylation.