视神经脊髓炎和经典型多发性硬化患者的Kaplan-Meier分析

Kaplan-Meier Analysis of Neuromyelitis Optica and Classical Multiple Sclerosis Patients

目的提高对视神经脊髓炎(NMO)和经典型多发性硬化(CMS)的诊治水平。方法回顾性分析142例NMO和CMS患者的临床资料,并对病程≥5年的65例NMO和CMS患者做Kaplan-Meier分析。结果在起始临床表现中,感觉缺失和视物模糊多见于NMO,眼球震颤和共济失调多见于CMS。CMS患者Kaplan-Meier曲线明显高于NMO患者。结论与CMS比较,NMO残疾进展更快,正确区分NMO和CMS有利于二者治疗。

Objective To improve the clinical level for diagnosing and treating neuromyelitis optica and multiple sclerosis. Methods The clinical data of 142 neuromyelitis optica and classical multiple sclerosis cases were retrospectively analyzed, Kaplan-Meier curve of 65 neuromyelitis optica and multiple sclerosis cases was drawn. Results Sensory loss and blurred vision of neuromyelitis optia cases were more frequent than that of classical multiple sclerosis as the initial manifestation. Nystagmus and ataxia of classical multiple sclerosis were more frequent than that of neuromyelitis optica as the initial manifestation, Kaplan-Meier curve of multiple sclerosis patients was higher than that of neuromyelitis optica＇ s. Conclusions The progression of disahillty in neuromyelitis optica cases was faster than that of classical multiple sclerosis. It was important to differentiate neuromyelitis optica and classical multiple sclerosis correctly in clinical practice.