植入5-氟脲嘧啶缓释剂在直肠癌根治术中的应用研究

Study of sustained-release 5-fluorouracil implantation in the treatment for rectal carcinoma

目的评价5-氟脲嘧啶(5-FU)缓释剂在直肠癌术中植入的临床疗效。方法对161例直肠癌拟手术者采用配对设计分为两组,缓释剂组85例,患者于直肠癌根治术中采用5-FU缓释剂局部植入化疗;普通化疗组76例,于直肠癌根治术后行常规化疗。两组患者均随访2年,观察其不良反应、肿瘤复发率及患者死亡率。结果与普通化疗组患者相比,缓释剂组患者无明显不良反应,肿瘤复发少,患者死亡率低。结论术中植入5-FU缓释剂效果明显,能减少复发和转移,患者耐受性良好,可望提高直肠癌根治术后的疗效。

Objective To evaluate the clinical efficacy of sustained - release 5 - fluorouracil （5 - FU） implantation in the treatment of rectal carcinoma. Methods One hundred and sixty one cases of rectal carcinoma were divided into two groups by matching. During the radical resection of rectal carcinoma, sustained-release 5 -FU implantation was performed in 85 cases, The remaining 76 cases were treated with routine chemotherapy after radical resection. Patients in the two groups were followed up for two years, adverse reaction, tumor recurrence rate and mortality rate of the patients were observed. Results Compared with the patients in routine chemotherapy group, the patients in sustained - release 5 - FU implantation group had no obvious adverse reaction, and had less tumor recurrence and low mortality rate. Conclusion Sustained - release 5 - FU implantation can reduce recurrence and metastasis and can be well tolerated, it may enhance the therapeutic effect on rectal carcinoma after radical resection.