口服半胱胺对奶山羊血浆及乳中生长抑素、生长激素水平的影响

Effect of Oral Cysteamine on the Levels of Somatostatin and Growth Hormone in Plasma and Milk of Dairy Goats

用４只河南本地泌乳奶山羊进行自身对照试验。试验期每隔５ｄ添加半胱胺１次，剂量为１００ｍｇ·ｋｇ－１ＢＷ，共喂３次。与对照期相比，试验期奶山羊血浆生长抑素（ＳＳ）含量明显下降（对照期（２８６±０５９）ｎｇ·ｍＬ－１，试验期（１１３±０２１）ｎｇ·ｍＬ－１，Ｐ＜００１），血浆生长激素（ＧＨ）平均水平显著提高（对照期（１１９±０２５）ｎｇ·ｍＬ－１，试验期（１３０±０２３）ｎｇ·ｍＬ－１，Ｐ＜００５），ＧＨ峰值变化不明显，基线水平有所提高（对照期（０９４±０２４）ｎｇ·ｍＬ－１，试验期（１０８±０１８）ｎｇ·ｍＬ－１，Ｐ＞００５）；乳中ＳＳ含量明显下降（对照期（０１５±００２）ｎｇ·ｍＬ－１，试验期（００５±００１）ｎｇ·ｍＬ－１，Ｐ＜００１），ＧＨ水平显著升高（对照期（１１１±００５）ｎｇ·ｍＬ－１，试验期（１２３±００９）ｎｇ·ｍＬ－１，Ｐ＜００５）。说明口服半胱胺能耗竭泌乳奶山羊的ＳＳ，改变ＧＨ分泌模式。

Four Henan local dairy goats of lactation were used to study the effect of oral cysteamine (CS) on the levels of somatostatin (SS) and growth hormone(GH) in plasma and milk in a self-control design.CS was added once every five days for three times (100mg·kg -1 BW) during the experimental period.In comparison with the control,the level of plasma SS dramatically decreased by 60.5% (P< 0.01 ) and the level of plasma mean GH enhanced by 9.2% (P<0.05),the baseline level of GH increased by 14.9% (P>0 05),and the peak amplitude of GH had no significant change in CS treated period.Meanwhile,the level of milk SS decreased by 66.7%(P<0.01),and the concentration of milk GH enhanced by 10.8%(P<0.05).The results indicate oral CS might deplete SS in dairy goats of lactation and change the model of GH secretion.